In post menopausal women, high t10, c12 CLA supplementation increased inflammatory markers and lipid peroxidation when compared to CLA “supplementation” with milk (containing, remember, mostly c9, t11).In other words, it wasn’t CLA as you’d get from grass-fed butter or pastured lamb shoulder chops. The safflower oil group saw improved insulin sensitivity, higher HDL, and lower inflammation. CLA loses a head-to-head match with safflower oil.T10, c12 CLA supplements increased inflammation and insulin resistance.T10, c12 CLA supplements worsened metabolic syndrome in men.In both wild-type and lab mice, the t10, c12 isomer stimulated mammary tumor growth, while c9, t11 isomers had a neutral effect.Healthy humans taking trans-10, cis-12 CLA supplements had increased triglycerides, LDL-HDL ratios, and total cholesterol-HDL ratios when compared to patients taking supplements based on cis-9, trans-11.
Cis 9 trans 11 cla supplement full#
However, while the t10,c12 isomer looks to be better at burning body fat, it comes at a cost. In a totally unsurprising twist, results change when you start feeding the stuff to live organisms and paying attention to the full effects (beyond just “does it result in 2% more fat loss?”). It also showed promise as a promoter of lean mass versus fat mass in humans.In another in vitro study, this time connective tissues isolated from human body fat, t10, c12 inhibited lipogenesis, or (something analogous to) body fat creation, while c9, t11 did not.T10, c12 can inhibit the growth of human colon cancer cells in vitro (with c9, t11 having no effect).Are CLA Supplements Healthy?Īt first glance, they seem effective in isolated in vitro studies and can help people lose body fat. Supplement makers have the luxury of focusing on other isomers, of course, so they typically produce CLA supplements containing equal amounts c9, t11 and t10, c12. In fact, c9, t11 CLA accounts for between 80-95% of the CLA in ruminant and dairy fat, with t10, c12 making up most of the remainder. Same type of molecules – different arrangement. CLA with a trans-10, cis-12 isomer is also evident, but in far scanter quantities. An isomer called cis-9, trans-11 (or c9, t11) isomer is the primary one. Then there are the stalwarts, those ruminant stomachs filled with microscopic bacterial sweatshops toiling away as they convert unsaturated fats to saturated fats and make various CLA isomers in the process.
You’ve got the new guys creating the stuff on a massive scale, getting their hands dirty in the lab, converting linoleic acid derived from safflower or sunflower oil into various isomers of CLA. What about CLA supplements? Is synthetic CLA just as good for you as naturally-occurring CLA? What is a CLA Supplement?Ĭonjugated linoleic acid production is a booming industry with many players.